abstract：BACKGROUND:Abciximab reduces the thrombotic complications of angioplasty. It is also used, as a 'bail out' treatment when angioplasty is complicated by thrombus but its speed of action is not known. This study sought to establish how quickly abciximab blocks the aggregation of both quiescent and activated platelets to ...

journal_title：Journal of thrombosis and thrombolysis

authors： Dalby MC,Davidson SJ,Burman JF,Sigwart U,Davies SW

更新日期：2002-06-01 00:00:00

abstract：:Data regarding possible mechanisms of aspirin (ASA) resistance in patients with recurrent myocardial infarction (MI) or vascular ischemia are limited. Five major possible mechanisms of ASA resistance are documented in the primary literature and are discussed in this paper. These mechanisms include: (1) inadequate bloc...

journal_title：Journal of thrombosis and thrombolysis

authors： Cambria-Kiely JA,Gandhi PJ

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Radiographic contrast agents inhibit fibrinolysis, although by poorly defined pathways. The purpose of this study was to define specific mechanisms by which contrast agents inhibit clot lysis. METHODS AND RESULTS:Diatrizoate (high osmolar ionic agent), ioxaglate (low osmolar ionic), and ioversol (nonionic) ...

journal_title：Journal of thrombosis and thrombolysis

authors： Farrehi PM,Zhu Y,Fay WP

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Sulfonylurea compounds may impair ischemic preconditioning and endogenous fibrinolysis. Increased mortality has been reported in diabetics receiving these drugs prior to admission for acute myocardial infarction when treated by direct angioplasty. Although thrombolytics are currently employed far more freque...

journal_title：Journal of thrombosis and thrombolysis

authors： Halkin A,Roth A,Jonas M,Behar S

更新日期：2001-10-01 00:00:00

abstract：:The duration of oral anticoagulant therapy for venous thromboembolism (VTE) depends on the risk of recurrence if treatment is stopped and the risk of bleeding if treatment is continued. If the risk of recurrence is low (e.g., thrombosis provoked by a major reversible risk factor such as surgery), 3 months of treatment...

journal_title：Journal of thrombosis and thrombolysis

authors： Kearon C

更新日期：2001-09-01 00:00:00

abstract：:Point-of-care whole blood coagulation tests are critical in the management of patients who undergo percutaneous coronary intervention. The Hemochron and HemoTec devices have been traditionally used to measure the activated clotting time (ACT) in the cardiac catheterization laboratory. The heparin management test (HMT)...

journal_title：Journal of thrombosis and thrombolysis

authors： Tsimikas S,Beyer R,Hassankhani A

更新日期：2001-05-01 00:00:00

abstract：:The goal of platelet function testing in the catheterization laboratory is to provide information about the platelet contributions to the risk of thrombotic or hemorrhagic events and optimization of anti-platelet therapy for percutaneous interventions. We present several illustrative cases in which platelet monitoring...

journal_title：Journal of thrombosis and thrombolysis

authors： Mukherjee D,Chew DP,Robbins M,Yadav JS,Raymond RE,Moliterno DJ

更新日期：2001-04-01 00:00:00

abstract：:In a previous study, we observed that one injection of 500 microg of DNA for the plasmid encoding for vascular endothelial growth factor (ph VEGF(165)) into one site in a rat myocardial infarction model resulted in neovascularization confined to angiomatous structures that did not contribute to regional myocardial blo...

journal_title：Journal of thrombosis and thrombolysis

authors： Kloner RA,Dow J,Chung G,Kedes LH

更新日期：2000-12-01 00:00:00

abstract：:Since the reports by Weismann and Tobin in 1958 and Roberts et al. in 1964 called attention to paradoxical thrombosis in patients treated with heparin, the thrombotic aspect of the heparin-induced thrombocytopenia syndrome (HIT) has been emphasized. Yet to this day, the mechanism of thrombosis associated with HIT (HIT...

journal_title：Journal of thrombosis and thrombolysis

authors： Walenga JM,Jeske WP,Messmore HL

更新日期：2000-11-01 00:00:00

abstract：:Measurements of infarct size by use of tripenyltetrazoliumchloride (TTC) is a widely accepted method used to delineate the extent of myocardial necrosis following coronary occlusion and reperfusion in various animal experiments. There is controversy, however, regarding the optimal reperfusion time for estimating the m...

journal_title：Journal of thrombosis and thrombolysis

authors： Schwarz ER,Somoano Y,Hale SL,Kloner RA

更新日期：2000-10-01 00:00:00

abstract：:It has been reported that platelet expression and plasma levels of soluble P-selectin are increased in patients with unstable coronary artery syndromes. However, the origin of soluble P-selectin remains unknown. We sought to determine whether platelet expression of P-selectin correlates with plasma levels in the popul...

journal_title：Journal of thrombosis and thrombolysis

authors： Gurbel PA,Kereiakes DJ,Serebruany VL

更新日期：2000-08-01 00:00:00

abstract：:This study was intended to evaluate the cost-effectiveness of anticoagulation clinic care and self-testing for the management of patients on chronic warfarin therapy. Using a 5-year Markov model, we evaluated the health and economic outcomes associated with each of three different anticoagulation management approaches...

journal_title：Journal of thrombosis and thrombolysis

authors： Lafata JE,Martin SA,Kaatz S,Ward RE

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:The available evidence suggests strongly that intravascular thrombosis is mediated predominantly by tissue-factor and its activation of factor X, which in the presence of factor Va, calcium, and phospholipid (prothrombinase complex) effectively converts prothrombin to thrombin. In vitro experiments have show...

journal_title：Journal of thrombosis and thrombolysis

authors： Spencer FA,Ball SP,Zhang Q,Liu L,Benoit S,Becker RC

更新日期：2000-04-01 00:00:00

abstract：:Increased level of soluble cell adhesion molecules may be a marker for atherosclerosis and/or reflect complication of the atherosclerotic plaque. To test whether expression of cell adhesion molecules is more pronounced in unstable versus stable coronary plaques, we measured the serum level of soluble E-selectin (sE-se...

journal_title：Journal of thrombosis and thrombolysis

authors： Galvani M,Ferrini D,Ottani F,Nanni C,Ramberti A,Amboni P,Iamele L,Vernocchi A,Nicolini FA

更新日期：2000-01-01 00:00:00

abstract：:We assessed the contribution of serum homocysteine levels, an independent risk factor for vascular disease, and of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation to the variability of carotid intimal-medial thickness (IMT) in patients with non-insulin-dependent diabetes mellitus (NIDDM). Ninety-five pa...

journal_title：Journal of thrombosis and thrombolysis

authors： Mazza A,Motti C,Nulli A,Pastore A,Andreotti F,Ammaturo V,Bianco P,Santoro E,Federici G,Cortese C

更新日期：1999-10-01 00:00:00

abstract：:Plasminogen activator inhibitor (PAI-1), a member of the serine protein family, is the most active in vivo inhibitor of fibrinolysis induced by plasminogen, tissue plasminogen activator (tPA), and urokinase type plasminogen activator (uPA). While the association between elevated PAI-1 and thrombogenesis has been well ...

journal_title：Journal of thrombosis and thrombolysis

authors： Senno SL,Pechet L

更新日期：1999-08-01 00:00:00

abstract：:On stimulation of platelets with agonists, for example, thrombin, a rapid rise in intracellular pH is observed. This alkalinization is mediated by an increase in transport activity of the Na(+)/H(+) exchanger isoform NHE1. In addition to this Na(+)/H(+) exchange mechanism, platelets express bicarbonate/chloride exchan...

journal_title：Journal of thrombosis and thrombolysis

authors： Rosskopf D

更新日期：1999-07-01 00:00:00

abstract：:Warfarin is a commonly used medication with a narrow therapeutic index. The initiation of warfarin requires consideration of a variety of factors, which include reviewing the indications and contraindications for this agent, performing a thorough clinical assessment along with a risk-benefit analysis for anticoagulati...

journal_title：Journal of thrombosis and thrombolysis

authors： Erban S

更新日期：1999-04-01 00:00:00

abstract：:We have applied the low molecular weight heparin dalteparin as once-daily subcutaneous injections to the treatment of deep vein thrombosis (DVT) on an outpatient basis since 1994. Until today, 377 consecutive patients with DVT below the inguinal ligament have been treated at home with dalteparin. The patients administ...

journal_title：Journal of thrombosis and thrombolysis

authors： Stockelberg D,Hansson E,Jonson T

更新日期：1998-09-01 00:00:00

abstract：:Poloxamer 188 is a surfactant with hemorheological, antithrombotic, and neutrophil-inhibitory properties. This agent has been demonstrated to reduce infarct size and to improve left ventricular function in animal models of myocardial infarction and reperfusion, and recently in a randomized trial of patients receiving ...

journal_title：Journal of thrombosis and thrombolysis

authors： Kelly RF,Hursey TL,Patel RB,Parrillo JE,Schaer GL

更新日期：1998-07-01 00:00:00

abstract：:The objective of this study were to assess the impact of a quality assurance effort on the door-to-needle time and the choice of thrombolytic agent for the management of acute myocardial infarction in the emergency department. The study design involved a prospective collection of data on a series of consecutive patien...

journal_title：Journal of thrombosis and thrombolysis

authors： Guidry UA,Paul SD,Vega J,Harris C,Chaturvedi R,O'Gara PT,Eagle KA

更新日期：1998-05-01 00:00:00

abstract：:Thrombolytic therapy has become a standard treatment for selected patients with acute myocardial infarction (MI). Various thrombolytic agents have been shown to decrease mortality. However, current thrombolytic agents still suffer significant shortcomings, such as a low optimal reperfusion rate delayed reperfusion. an...

journal_title：Journal of thrombosis and thrombolysis

authors： Serebruany VL,Jang IK,Giugliano RP,Massey TJ,Schwarz Jr RP

更新日期：1998-01-01 00:00:00

abstract：:The initial treatment of acute venous thrombosis using low-molecular-weight heparin (LMWH) in the outpatient setting has been shown to be feasible, effective, and safe for selected patients when compared with in-hospital treatment using continuous intravenous heparin. There will always be a significant population of p...

journal_title：Journal of thrombosis and thrombolysis

authors： Pineo GF,Hull RD

更新日期：1998-01-01 00:00:00

abstract：:The objective of this study was to determine if aspirin users presenting with acute coronary syndromes are at higher risk for subsequent clinical events. In a trial evaluating combination antithrombotic therapy in resting angina or non-Q-wave myocardial infarction (MI), patients were prospectively dichotomized on admi...

journal_title：Journal of thrombosis and thrombolysis

authors： Cohen M,Adams PC,McBride R,Blanke H,Fuster V V

更新日期：1997-01-01 00:00:00

abstract：:Background: Renal vein thrombosis (RVT) complicating the nephrotic syndrome is associated with a poor prognosis. Methods/Results: RVT was diagnosed in 12 of 60 patients with a diagnosis of nephrotic syndrome suggested by computed tomography (CT) and subsequently confirmed by selective renal angiography. Fifty patients...

journal_title：Journal of thrombosis and thrombolysis

authors： Wu ZL,Zhou KR,Liao Lt

更新日期：1996-01-01 00:00:00

abstract：:Moderate use of alcohol has shown protective effects in coronary artery disease, while excessive use has been associated with cardiomyopathy and hypertension. Since alcohol is a vasodilator, we postulated that it might have protective effects when administered acutely in the setting of ischemia/reperfusion. Therefore,...

journal_title：Journal of thrombosis and thrombolysis

authors： Bellows SD,Hale SL,Kloner RA

更新日期：1996-01-01 00:00:00

abstract：:Time to treatment with thrombolytic therapy has been recognized as an important factor in the treatment of patients with acute myocardial infarction: By restoring infarct-related artery patency earlier, clinical outcome is improved. Of the several components of time delay between the onset of pain to opening of the ar...

journal_title：Journal of thrombosis and thrombolysis

authors： Cannon CP

更新日期：1996-01-01 00:00:00

abstract：:Objective: To define the changing incidence, risk, and therapy of acute myocardial infarction (A311). Data sources: Review of contemporary AMI data from the University of Alberta Hospitals, six other sites of the Clinical Quality Improvement Network (CQIN), and other Canadian and international centers. Data synthesis:...

journal_title：Journal of thrombosis and thrombolysis

authors： Montague T,Montague P,Barnes M,Taylor L,Wowk L,Fassbender K,Ackman M,Martin S,Armstrong PW,Teo K

更新日期：1996-01-01 00:00:00

abstract：:Acute myocardial infarction is initiated by plaque disruption of a fatty plaque with a thin fibrous cap which has been infiltrated by macrophages. The macrophages are attracted and stimulated by oxidized lipids to secrete metalloproteinases which dissolve collagen and arterial wall matrix and to synthesize tissue fact...

journal_title：Journal of thrombosis and thrombolysis

authors： Chesebro JH,Badimon JJ,Hassinger NL,McBane RD,Fuster V V

更新日期：1995-01-01 00:00:00

abstract：:The use of magnesium therapy for acute myocardial infarction remains controversial despite recent clinical trials such as ISIS-4. Magnesium has numerous beneficial effects in the setting of myocardial infarction, including inhibitory effects on platelet aggregation. Clinical trials of magnesium therapy for myocardial ...

journal_title：Journal of thrombosis and thrombolysis

authors： Rabbani LE

更新日期：1995-01-01 00:00:00

abstract：:The benefits of thrombolytic therapy in the treatment of acute myocardial infarction are incontrovertible. Large-scale studies combining angiographic and clinical end-points have demonstrated a perfusion-mortality relationship, with the highest survival rate among patients with early restoration of TIMI grade 3 corona...

journal_title：Journal of thrombosis and thrombolysis

authors： Moliterno DJ,Harrington RA,Califf RM,Rapold HJ,Topol EJ

更新日期：1995-01-01 00:00:00

abstract：:Background: There is compelling evidence that coronary atherosclerosis represents a chronic active process characterized by inflammation, impaired fibrinolysis, intermittent plaque rupture, and luminal thrombosis. Identifying readily measurable plasma markers of procoagulant activity may have an important role in both...

journal_title：Journal of thrombosis and thrombolysis

authors： Rho R,Tracy RP,Bovill EG,Ball SP,Becker RC

更新日期：1995-01-01 00:00:00

abstract：:While antithrombotic therapy of acute myocardial infarction is clearly beneficial, substantial controversy exists regarding the optimal regimen. In particular, while aspirin alone has proven highly effective in reducing rates of reinfarction, stroke, and death following acute coronary occlusion, heparin has not clearl...

journal_title：Journal of thrombosis and thrombolysis

authors： Ridker PM,O'Donnell CJ,Hennekens CH

更新日期：1995-01-01 00:00:00

abstract：:Background: Thrombolytic therapy has been shown to reduce mortality in select patients with acute myocardial infarction (AMI). The determinants of eligibility for therapy are changing as more information about the safety and efficacy of thrombolytic therapy is obtained. In the United States, there is some concern that...

journal_title：Journal of thrombosis and thrombolysis

authors： Maynard C,Martin JS,Hallstrom AP,Weaver WD

更新日期：1995-01-01 00:00:00

abstract：:The adverse impact of the development of cardiogenic shock in the setting of acute myocardial infarction was first described by Killip and Kimball in 1967. While the in-hospital mortality rate in patients with myocardial infarction and no evidence of heart failure was only 6%, the mortality rate in those patients who ...

journal_title：Journal of thrombosis and thrombolysis

authors： Levine GN,Hochman JS

更新日期：1995-01-01 00:00:00